Metformin is the mostly widely prescribed drug in the world to treat type 2 diabetes. It may also be a key to slow aging, mitigate age-related diseases, extend lifespan and increase health span. All in a pill that costs pennies a day, is safe, and has been scientifically shown to impact age-related biological changes.
It’s not exactly clear just how metformin affects aging, but researchers think it acts on several different hallmarks of aging—changes at the cellular, chromosomal and molecular levels which accumulate over time. These transformations are what can lead to onset of conditions like heart disease, diabetes, some cancers, or dementia, often known as “diseases of aging.”
Result from a randomized, double-blind, placebo-controlled, crossover trial revealed that metformin had both metabolic and non-metabolic effects associated with aging in the elderly, providing evidence for the anti-aging effect of metformin. This notion is further supported from results from preclinical studies showing that metformin could extend the lifespan of C. elegans, an invertebrate, and mice
Research in humans suggests that metformin can impact mortality. A meta-analysis published in 2017 that included 53 different studies concluded that metformin reduces all-cause mortality and diseases of aging, independent of its effect on diabetes.
The analysis found that the use of metformin lowers the risk of cancer, cardiovascular disease, stroke, and death, says Justice.
“The findings on mortality risk are remarkable. Persons with diabetes taking metformin have a lower risk of death than both those with diabetes who are not taking metformin or taking other drugs (like sulphonylureas or insulin) and those without diabetes,” she says.
Diabetes is thought to “accelerate” aging, meaning people with diabetes have a greater risk of getting another chronic disease and greater risk of mortality, says Justice. “That someone taking metformin with diabetes may have a lower risk of death than someone without diabetes is really promising for potential effects on human lifespan. But this needs to be tested definitively in a randomized clinical trial, not just epidemiology or medical records,” she says.
Researchers have known for some time that metformin does more than just help lower blood sugar, says Chris Triggle, PhD, a researcher and professor of pharmacology at Weill Cornell Medicine in Doha, Qatar. “The use of metformin has been shown to reduce the risk of and mortality associated with cardiovascular disease,” he says.
There’s also evidence that it could help with preventing age-related cognitive dysfunction, according to a study published in January 2021 in Aging Cell.
https://fortune.com/well/2023/05/04/metformin-anti-aging-longevity-risks-side-effects/#
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965502/
Personal Note: I have been taking metformin for several decades now. Will it slow down my aging?
My Quote of the Day: A Man's feeling of good-will towards others is the strongest magnet for drawing good-will towards himself. Lord Chesterfield, 1694-1773, English Statesman
2 comments:
While you're on the topic of Diabetes medication, have you heard of the fruit Loquat? It comes from a fruit bearing tree originally from China which has been cultivated in other parts of the world, and the fruit or its leaves have properties which help lower the blood sugar. The fruit usually ripens bright orange during early summer and when it is off season, you can boil the leaves and drink it like a tea. You may be interested in this fruit tree to ward off the ill effects of diabetes.
That is why if you remember As I said you look 10 years younger at your age now becauae of what said that you are taking that drugs metformin which help prolong
anti-aging..May I ask if how do you feel while taking this drug? and how long been using this?
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